Metabolomics

Metabolomics is the study of small biomolecules or “metabolites” endogenous to a biological system. These small molecules are essential for an organism’s metabolism or to a particular metabolic process. Metabolites are an organism’s workforce, providing signals and information from the environment and genes. They are the intermediate products of metabolic reactions catalyzed by various enzymes that occur naturally within a biological system. Metabolomics is therefore considered to provide a direct functional readout of the physiological state of an organism, cell, or tissue. Understanding the metabolism is integral to comprehending the phenotypic behavior of all living things.

SGS AXYS is pioneer in commercially available targeted metabolomics for ecotoxicology applications. We offer a suite of 250+ endogenous metabolites in multiple tissue compartments, serum and urine.  SGS AXYS is also the only commercial lab in North America that is IEC/ISO 17025-accredited for its targeted metabolomics assay.

The SGS AXYS Advantage

  • Quantitative, concentration-rich data is amenable to statistical analysis, enabling comparisons across studies, time and species.
  • Specialized sample handling, extractions, and hold times minimize analytical artifacts
  • Multiplexed approach to maximize throughput while minimizing costs
  • High sensitivity methods require only small sample sizes
  • ISO/IEC 17025 independently accredited methodology ensures data quality
  • À la carte system of metabolite lists for focused investigation, or multi-panel lists for broad phenotyping.
  • Project management, study design, data review, and interpretation by PhD/Masters scientists.

Our Offering

Metabolite Class Number of Metabolites
Amino Acid

21

Biogenic Amine

22

Acylcarnitine

40

Glycerophospholipid

89

Sphingolipid

15

Non-conjugated bile acid

5

Glycine-conjugated bile acid

3

Taurine-conjugated bile acid

5

Saturated fatty acid

4

Monounsaturated fatty acid

1

Polyunsaturated fatty acid

13

Sugar

1

TCA/Glycolysis

18

Androgen

7

Estrogen

4

Progestegen

2

Corticosteroid

7

Application Spotlight

In a unique study, Simmons et al. 2017 used metabolomics and PPCP measurements in goldfish plasma from SGS AXYS to understand the occurrence of PPCPs, and biological and behavioral changes that could be linked to the occurrence. They found using sensitive PPCP measurements that low levels of serotonin altering (SSRI) drugs like fluoxetine detected in the fish could me linked to neutrotransmitter metabolites (such as serotonin). Further more, metabolomic and proteomic changes in these fish could be linked to observed behavioural changes in the fish.