Method Development

The go to laboratory for new methods!

The industry-leading SGS AXYS team of Ph.D. chemists and research scientists have decades of successful experience developing methods to solve our clients’ unique needs. The quality of our analytical approaches has been recognized by many key agencies and our methods are the backbone of multiple US EPA methods including 1668 for PCBs. We bring this unique ability to deliver validated methods to our industry, government, and academic clients. Most recently, we have introduced exciting ultra-trace GC-MS/MS capabilities to dioxin, PCB and pesticide analysis and are working on validating the isotope dilution method for PFAS analysis in all environmental matrices 

Our Capabilities & Approach

We are a full service targeted mass spectrometry method development laboratory.  We use our research expertise to review literature for related studies, and we translate that knowledge and our own experience with the compounds or related problems to develop a method that will accomplish the goal.  Then we test and optimize each component of the method to ensure its validity and overall performance.  We validate and compile that method into the tools necessary to conduct that analysis in a repeatable, defensible manner with QA/QC standards.  If required, we seek accreditation for the method.  Our analyst team helps you leverage that method to get the data and insights you need from your research initiative.  Finally, our scientists regularly collaborate with our clients to produce posters, presentations and peer-review publications on the methods themselves or the innovative projects where they are used.  

Our Development History

We have worked successfully with groups in all types of organizations, at all stages of scientific understanding of a particular compound. Here’s just a few examples of the successful development projects under our belt. 

Method

Year

Remarks

Isotope Dilution PFAS Method in Aqueous, Solids and Tissue

2019 In Progress

Will be the basis of an EPA standard method pending
single/Multi-Lab Validation

Dioxins – GC-MS/MS

2018

In the process of becoming an alternate test method for EPA
1613

Neonicotinoid pesticides

2018

Low level PFAS in AFFF Foam

2018

Future standard published method

Bisphenols

2017

Expanded suite of bisphenol A and replacement chemistries

PCBs by GC-MS – EPA Method

2017

Validation of a method for the EPA

PFAS Total Oxidizable Precursor Analysis (TOP)

2017

Current-use brominated and chlorinated flame retardants

2015

Organophosphorous flame retardants

2014

Targeted Metabolomics

2014

Naphthenic acids

2009

Multi-residue pesticides

2005

Became EPA-1699

Polybrominated Diphenyl Ethers (PBDE)

2004

Became EPA 1614

PPCPs

2003

Became EPA 1694

PFAS Setup

2002

Hormones and sterols

2001

Became EPA 1698

PCBs – GC-HRMS

1991

Became EPA 1668 A

Dioxins – HRMS

1989

PCBS – GC-LRMS

1986

Basis of new EPA GC-MS congener method to replace aroclor
methods